研究人員在一項(xiàng)新研究中發(fā)現(xiàn)了一種被稱為“好膽固醇”的高密度脂蛋白(HDL)，能夠促發(fā)系統(tǒng)性紅斑狼瘡（SLE）和風(fēng)濕性關(guān)節(jié)炎患者動(dòng)脈粥樣硬化癥和心臟疾病的發(fā)生。

這種新型HDL叫做親炎癥性高密度脂蛋白(piHDL)。在研究中研究人員測定了來自154例女性SLE患者、73例年齡匹配的對照、50例風(fēng)濕性關(guān)節(jié)炎患者的piHDL。SLE患者的HDL中piHDL水平顯著高于對照組。同樣在10例確診為動(dòng)脈粥樣硬化癥的患者發(fā)現(xiàn)了piHDL。這種生物指標(biāo)在12例發(fā)生腦卒中的SLE患者中的6例同樣升高。

這樣研究是由美國加利福尼亞大學(xué)洛杉磯分校(UCLA, USA)David Geffen醫(yī)學(xué)院的Hahn醫(yī)生及其同時(shí)主持完成的。

Potential Biomarker for Lupus
 
Investigators in a new study have uncovered a form of high-density lipoprotein (HDL), known as the “good cholesterol,” which promotes atherosclerosis and heart disease in many people with systemic lupus erythematosus (SLE) and rheumatoid arthritis.

This new form of HDL is called pro-inflammatory (piHDL). In the study, researchers measured the presence of piHDL in samples of blood plasma from 154 women with SLE, 73 age-matched controls, and 50 women with rheumatoid arthritis. The HDL of those with SLE contained significantly more piHDL than the control group. Aslo, piHDL was found in eight of the 10 individuals with SLE determined to have atherosclerosis. The biomarker was similarly high in half of the 12 subjects with SLE who had suffered a stroke.

The study was conducted by Dr. Hahn and colleagues at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA, USA).